CSNK2B Antibody (C-term F168) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P67870 |
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Clone Names | 50908348 |
Gene ID | 1460 |
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Other Names | Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a, CSNK2B, CK2N, G5A |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7075e was selected from the C-term region of human CSNK2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CSNK2B (HGNC:2460) |
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Synonyms | CK2N, G5A |
Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CSNK2B is the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
References
Schwartz, E.I., et al., Mol. Cell. Biol. 24(21):9580-9591 (2004).Lee, G., et al., J. Biol. Chem. 279(8):6834-6839 (2004).Lim, A.C., et al., J. Biol. Chem. 279(6):4433-4439 (2004).Singh, D.K., et al., Virology 313(2):435-451 (2003).Szebeni, A., et al., J. Biol. Chem. 278(11):9107-9115 (2003).
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