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PDXK Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00764
Clone Names 4012310
Peptide ID 4012310
Additional Information
Gene ID 8566
Other Names Pyridoxal kinase, Pyridoxine kinase, PDXK, C21orf124, C21orf97, PKH, PNK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7079a was selected from the N-term region of human PDXK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C21orf124, C21orf97, PKH, PNK
Function Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous. Isoform 3 is detected in adult testis and spermatozoa
Research Areas
Citations (0)

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Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.

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$ 80.00
Cat# BP7079a
Availability: In Stock
Bulk Size
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