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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Deoxyguanosine Kinase (DGUOK) Antibody (N-term) Blocking peptide   

Deoxyguanosine Kinase (DGUOK) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q16854
Other Accession NP_550438
Clone Names 4010909
Peptide ID 4010909
Additional Information
Gene ID 1716
Other Names Deoxyguanosine kinase, mitochondrial, dGK, DGUOK, DGK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7086a was selected from the N-term region of human DGUOK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DGK
Function Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Cellular Location Mitochondrion.
Tissue Location Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
Research Areas
Citations (0)

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Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.

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$ 80.00
Cat# BP7086a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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