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DCK Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P27707
Clone Names 4010908
Peptide ID 4010908
Additional Information
Gene ID 1633
Other Names Deoxycytidine kinase, dCK, DCK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7087b was selected from the C-term region of human DCK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCK
Function Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Cellular Location Nucleus.
Research Areas
Citations ( 0 )


Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.


Chottiner, E. G., et al. Proc. Nat. Acad. Sci. 88: 1531-1535 (1991).

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$ 80.00
Cat# BP7087b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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