|Other Names||Adenosine kinase, AK, Adenosine 5'-phosphotransferase, ADK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7091b was selected from the C-term region of human ADK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Widely expressed. Highest level in placenta, liver, muscle and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Adenosine kinase is an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.
Szkotak, A.J., et al., J. Membr. Biol. 192(3):169-179 (2003).Singh, B., et al., DNA Cell Biol. 20(1):53-65 (2001).Van Rompay, A.R., et al., Eur. J. Biochem. 261(2):509-517 (1999).Mathews, I.I., et al., Biochemistry 37(45):15607-15620 (1998).McNally, T., et al., Biochem. Biophys. Res. Commun. 231(3):645-650 (1997).
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