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NEK8 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86SG6
Clone Names 4012309
Peptide ID 4012309
Additional Information
Gene ID 284086
Other Names Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Nima-related protein kinase 12a, NEK8, JCK, NEK12A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7095b was selected from the C-term region of human NEK8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEK8
Synonyms JCK, NEK12A
Function Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells
Tissue Location Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma
Research Areas
Citations (0)

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NEK8 is a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. NEK8 highest expression occurs in adult heart, followed by pancreas, skeletal muscle, brain, liver, kidney, lung and placenta. NEK is required for renal tubular integrity, and is present in most primary carcinomas.

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$ 80.00
Cat# BP7095b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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