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Activin A Receptor Type IC (ACVR1C) Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NER5
Clone Names 5062857
Peptide ID 5062857
Additional Information
Gene ID 130399
Other Names Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (HGNC:18123)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7102b was selected from the Center region of human ACVR1C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACVR1C (HGNC:18123)
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy
Research Areas
Citations (0)

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Background

ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

References

Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004).Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004).Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003).Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004) (): ().Bondestam, J., et al., Cytogenet. Cell Genet. 95 (3-4), 157-162 (2001) (): ().

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$ 80.00
Cat# BP7102b
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