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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CDC42BPA Antibody (N-term) Blocking Peptide   

CDC42BPA Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5VT25
Clone Names 50908117
Additional Information
Gene ID 8476
Other Names Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH713361}, KIAA0451
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7120a was selected from the N-term region of human CDC42BPA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC42BPA {ECO:0000312|EMBL:CAH71336.1}
Synonyms KIAA0451
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
Cellular Location Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction This concentration is PH-domain dependent (By similarity)
Tissue Location Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
Research Areas
Citations (0)

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CDC42BPA is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization.


Dong, J.M., et al., Eur. J. Cell Biol. 81(4):231-242 (2002).Tan, I., et al., Mol. Cell. Biol. 21(8):2767-2778 (2001).Lam, L.T., et al., Hum. Mol. Genet. 9(14):2167-2173 (2000).Nakamura, N., et al., Genes Cells 5(7):571-581 (2000).Leung, T., et al., Mol. Cell. Biol. 18(1):130-140 (1998).

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$ 80.00
Cat# BP7120a
(40 western blots)
Availability: In Stock
Bulk Size
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