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CDK10 Antibody (N-term R5) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15131 |
|---|---|
| Clone Names | 50908121 |
| Gene ID | 8558 |
|---|---|
| Other Names | Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE, CDK10 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7121a was selected from the N-term region of human CDK10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDK10 |
|---|---|
| Function | Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium basal body |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase.
References
Kasten, M., et al., Oncogene 20(15):1832-1838 (2001).Sergere, J.C., et al., Biochem. Biophys. Res. Commun. 276(1):271-277 (2000).Crawford, J., et al., Genomics 56(1):90-97 (1999).Bullrich, F., et al., Cancer Res. 55(6):1199-1205 (1995).Li, S., et al., Cancer Res. 55(18):3992-3995 (1995).
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