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CIT Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14578 |
|---|---|
| Clone Names | 4011405 |
| Gene ID | 11113 |
|---|---|
| Other Names | Citron Rho-interacting kinase, CRIK, Serine/threonine-protein kinase 21, CIT, CRIK, KIAA0949, STK21 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7124a was selected from the Center region of human CIT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CIT |
|---|---|
| Synonyms | CRIK, KIAA0949, STK21 |
| Function | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CIT is a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. This protein exhibits dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. CIT plays an important role in the regulation of cytokinesis and the development of the central nervous system.
References
Liu, H., et al., J. Biol. Chem. 278(4):2541-2548 (2003).Di Cunto, F., et al., J. Biol. Chem. 273(45):29706-29711 (1998).
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