|Other Names||Fas-activated serine/threonine kinase, FAST kinase, FASTK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7129a was selected from the Center region of human FASTK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.|
|Cellular Location||Isoform 4: Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules.|
|Tissue Location||Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
FASTK is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis.
Li, W., et al., Mol. Cell. Biol. 24(24):10718-10732 (2004).Scherer, S.W., et al., Science 300(5620):767-772 (2003).Tian, Q., et al., J. Exp. Med. 182(3):865-874 (1995).Auffray, C., et al., C. R. Acad. Sci. III, Sci. Vie 318(2):263-272 (1995).
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