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GUCY2C Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P25092
Clone Names 8033116
Additional Information
Gene ID 2984
Other Names Heat-stable enterotoxin receptor, STA receptor, hSTAR, Guanylyl cyclase C, GC-C, Intestinal guanylate cyclase, GUCY2C, GUC2C, STAR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7136b was selected from the C-term region of human GUCY2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GUCY2C {ECO:0000303|PubMed:22521417, ECO:0000312|HGNC:HGNC:4688}
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:1718270, PubMed:11950846, PubMed:23269669, PubMed:22521417, PubMed:22436048). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1718270, PubMed:1680854). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596).
Cellular Location Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single- pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form
Research Areas
Citations (0)
citation

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Background

Guanylyl cyclase C (GUCY2C) is a transmembrane receptor expressed primarily in the intestine that regulates chloride secretion via the cystic fibrosis transmembrane conductance regulator. Binding of GUCY2C to either the endogenous peptide guanylin or the bacterially derived heat-stable enterotoxin STa, results in increased levels of cGMP and the stimulation of water and chloride secretion. In the case of exposure to STa, this leads to debilitating secretory diarrhea.

References

Singh, R., J. Biol. Chem. 278(27):24342-24349 (2003).Tien, Y.W., et al., Clin. Cancer Res. 9(13):4891-4896 (2003).Scott, R.O., et al., J. Biol. Chem. 277(25):22934-22941 (2002).Jaleel, M., et al., Biol. Reprod. 67(6):1975-1980 (2002).Park, J., et al., Cancer Epidemiol. Biomarkers Prev. 11(8):739-744 (2002).

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$ 277.78
Cat# BP7136b
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