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MARK1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9P0L2
Other Accession Q2HIY1
Clone Names 50908151
Peptide ID 50908151
Additional Information
Gene ID 4139
Other Names Serine/threonine-protein kinase MARK1, MAP/microtubule affinity-regulating kinase 1, PAR1 homolog c, Par-1c, Par1c, MARK1 (HGNC:6896)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7144a was selected from the N-term region of human MARK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MARK1 (HGNC:6896)
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm, cytoskeleton. Note=Appears to localize to an intracellular network.
Tissue Location Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Research Areas
Citations (0)

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MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK


Drewes, G., et al., Cell 89(2):297-308 (1997).

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$ 80.00
Cat# BP7144a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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