|Other Names||Mitogen-activated protein kinase kinase kinase 15, Apoptosis signal-regulating kinase 3, MAPK/ERK kinase kinase 15, MEK kinase 15, MEKK 15, MAP3K15, ASK3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7148a was selected from the N-term region of human MAP3K15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.|
|Tissue Location||Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Mitogen-activated protein (MAP) kinases, also known as extracellular signal-regulated kinases (ERKs)are thought to act as an integration point for multiple biochemical signals because they are activated by a wide variety of extracellular signals, are rapidly phosphorylated on threonine and tyrosine residues, and are highly conserved in evolution.
Isogai, T., et al., Unpublished (2004) (): ().
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