- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
MKNK2 Antibody (C-term) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| BP7152a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
MKNK2 Antibody (C-term) Blocking Peptide - Product info | |
| Primary Accession | Q9HBH9 |
| Clone Names | 4012628 |
| Calculated MW | 51875 Da |
MKNK2 Antibody (C-term) Blocking Peptide - Additional info | |
| Gene ID 2872 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7152a was selected from the C-term region of human MKNK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MKNK2 Antibody (C-term) Blocking Peptide - Protein Information | |
| Name MKNK2 | |
| Synonyms GPRK7, MNK2 | |
| Function Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses Involved in anti-apoptotic signaling in response to serum withdrawal | |
| Cellular Location Isoform 2: Nucleus, PML body. | |
| Tissue Location Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1 | |
MKNK2 Antibody (C-term) Blocking Peptide - Related products
AP7058a: MNK2 (MKNK2) Antibody (N-term)
AP7152a: MNK2 (MKNK2) Antibody (C-term)
RI13315: MKNK2 predesign siRNA
BP7058a: MKNK2 Antibody (N-term) Blocking Peptide
MKNK2 Antibody (C-term) Blocking Peptide - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MKNK2 may play a role in the response to environmental stress and cytokines. This protein appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
REFERENCES
Scheper, G.C., et al., Mol. Cell. Biol. 23(16):5692-5705 (2003).Knauf, U., et al., Mol. Cell. Biol. 21(16):5500-5511 (2001).Scheper, G.C., et al., Mol. Cell. Biol. 21(3):743-754 (2001).Slentz-Kesler, K., et al., Genomics 69(1):63-71 (2000).Haribabu, B., et al., Proc. Natl. Acad. Sci. U.S.A. 90(20):9398-9402 (1993).
