|Other Names||Myosin-IIIb, MYO3B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7155a was selected from the N-term region of human MYO3B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable actin-based motor with a protein kinase activity.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Expressed in retina, kidney and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Similar to other class III myosins, MYO3B contains an N-terminal kinase domain, followed by motor, neck, and tail domains. The MYO3B gene generates a variety of splice variants that contain 1 or 2 calmodulin-binding (IQ) motifs in the neck domain and 1 of 3 domains in the tail domain. Northern blot analysis showed expression of a 7-kb MYO3B transcript in human retina, but not in an RPE cell line; two 6- and 7-kb MYO3B transcripts in kidney; and a 4-kb transcript in testis.
Dose, A.C., et al., Genomics 79(5):621-624 (2002).
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