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PANK1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8TE04
Clone Names 4012330
Additional Information
Gene ID 53354
Other Names Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1, PANK1, PANK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7159a was selected from the N-term region of human PANK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PANK1
Synonyms PANK
Function [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Cellular Location Cytoplasm. [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome
Tissue Location [Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis
Research Areas
Citations (0)
citation

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Background

PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA.

References

Ramaswamy, G., et al., J. Lipid Res. 45(1):17-31 (2004).Ni, X., et al., Int. J. Biochem. Cell Biol. 34(2):109-115 (2002).Zhou, B., et al., Nat. Genet. 28(4):345-349 (2001).Westaway, S.K., et al., Int. J. Biochem. Cell Biol. 34 (12), 1629 (2002) (): ().Robishaw, J.D., et al., Am. J. Physiol. 248 (1 PT 1), E1-E9 (1985) (): ().

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$ 277.78
Cat# BP7159a
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Availability: 2 weeks
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