|Other Names||Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1, PANK1, PANK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7159a was selected from the N-term region of human PANK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the physiological regulation of the intracellular CoA concentration.|
|Tissue Location||Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA.
Ramaswamy, G., et al., J. Lipid Res. 45(1):17-31 (2004).Ni, X., et al., Int. J. Biochem. Cell Biol. 34(2):109-115 (2002).Zhou, B., et al., Nat. Genet. 28(4):345-349 (2001).Westaway, S.K., et al., Int. J. Biochem. Cell Biol. 34 (12), 1629 (2002) (): ().Robishaw, J.D., et al., Am. J. Physiol. 248 (1 PT 1), E1-E9 (1985) (): ().
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