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PBK Antibody (N-term N6) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96KB5
Clone Names 6071559
Additional Information
Gene ID 55872
Other Names Lymphokine-activated killer T-cell-originated protein kinase, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7164d was selected from the N-term region of human PBK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PBK
Synonyms TOPK
Function Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage.
Tissue Location Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
Research Areas
Citations (0)
citation

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Background

PBK is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

References

Nandi, A., et al., Blood Cells Mol. Dis. 32(1):240-245 (2004).Simons-Evelyn, M., et al., Blood Cells Mol. Dis. 27(5):825-829 (2001).Zhao, S., et al., Int. J. Biochem. Cell Biol. 33(6):631-636 (2001).Abe, Y., et al., J. Biol. Chem. 275(28):21525-21531 (2000).Gaudet, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(10):5167-5172 (2000).

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$ 277.78
Cat# BP7164d
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