|Other Names||Lymphokine-activated killer T-cell-originated protein kinase, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7164d was selected from the N-term region of human PBK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.|
|Tissue Location||Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.|
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Provided below are standard protocols that you may find useful for product applications.
PBK is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
Nandi, A., et al., Blood Cells Mol. Dis. 32(1):240-245 (2004).Simons-Evelyn, M., et al., Blood Cells Mol. Dis. 27(5):825-829 (2001).Zhao, S., et al., Int. J. Biochem. Cell Biol. 33(6):631-636 (2001).Abe, Y., et al., J. Biol. Chem. 275(28):21525-21531 (2000).Gaudet, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(10):5167-5172 (2000).
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