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PFTK1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O94921
Clone Names 50908183
Peptide ID 50908183
Additional Information
Gene ID 5218
Other Names Cyclin-dependent kinase 14, Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1, hPFTAIRE1, CDK14, KIAA0834, PFTK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7168a was selected from the N-term region of human PFTK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK14
Synonyms KIAA0834, PFTK1
Function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Cellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY
Tissue Location Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
Research Areas
Citations (0)

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PFTK1 elongs to the Ser/Thr protein kinase family (CDC2/CDKX subfamily)and is highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.PFTK1 may play a role in meiosis as well as in neuron differentiation and/or function (By similarity).


Scherer, S.W., et al., Science 300(5620):767-772 (2003).Yang, T., et al., Gene 267(2):165-172 (2001).Lazzaro, M.A., et al., J. Neurochem. 69(1):348-364 (1997).

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$ 80.00
Cat# BP7168a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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