|Other Names||Phosphoglycerate kinase 2, Phosphoglycerate kinase, testis specific, PGK2, PGKB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7170a was selected from the N-term region of human PGK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity).|
|Tissue Location||Mainly found in round spermatids. Localized on the principle piece in the sperm (at protein level). Testis- specific. Expression significantly decreased in the testis of elderly men.|
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Provided below are standard protocols that you may find useful for product applications.
PGK2 is a form of phosphoglycerate kinase unique to spermatozoa. The autosomal PGK2 gene lacks introns and contains characteristics of a processed gene. The conservation of function in this processed PGK2 gene and its tissue-specific expression in spermatogenesis suggests that it exists as a compensatory response to the inactivation of the X-linked PGK1 gene in spermatogenic cells before meiosis.
Zhang, L.P., et al., Biol. Reprod. 60(6):1329-1337 (1999).McCarrey, J.R., et al., Dev. Genet. 19(4):321-332 (1996).Blanche, H., et al., Genomics 9(3):420-428 (1991).McCarrey, J.R., et al., Nature 326(6112):501-505 (1987).Michelson, A.M., et al., J. Biol. Chem. 260(11):6982-6992 (1985).
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