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PIM3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86V86
Clone Names 50908186
Peptide ID 50908186
Additional Information
Gene ID 415116
Other Names Serine/threonine-protein kinase pim-3, PIM3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7171a was selected from the C-term region of human PIM3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIM3
Function Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
Cellular Location Cytoplasm.
Tissue Location Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs
Research Areas
Citations (0)

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PIM3 is a memberof the Ser/Thr protein kinase family that may be involved in cell cycle progression and anti-apoptosis process. This protein has been implicated in proliferation of human hepatoma cell lines. PIM3 is widely expressed, with the exception of no expression observed in colon, thymus, and small intestine. PIM3 is expressed in human hepatoma cell lines but not in normal liver tissues.


Mikkers, H., et al., Mol. Cell. Biol. 24(13):6104-6115 (2004).Eichmann, A., et al., Oncogene 19(9):1215-1224 (2000).

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$ 80.00
Cat# BP7171a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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