|Other Names||Phosphomevalonate kinase, PMKase, hPMK, PMVK, PMKI|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7175a was selected from the C-term region of human PMVK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung|
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Provided below are standard protocols that you may find useful for product applications.
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate as the fifth reaction of the cholesterol biosynthetic pathway.
Hogenboom, S., et al., J. Lipid Res. 45(4):697-705 (2004).Strausberg RL, et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Olivier, L.M., et al., J. Lipid Res. 40(4):672-679 (1999).Chambliss, K.L., et al., J. Biol. Chem. 271(29):17330-17334 (1996).Krisans, S.K., et al., J. Biol. Chem. 269(19):14165-14169 (1994).
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