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PMVK Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15126 |
|---|---|
| Clone Names | 4012328 |
| Gene ID | 10654 |
|---|---|
| Other Names | Phosphomevalonate kinase, PMKase, hPMK, PMVK, PMKI |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7175a was selected from the C-term region of human PMVK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PMVK |
|---|---|
| Synonyms | PMKI |
| Function | Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. |
| Cellular Location | Cytoplasm, cytosol |
| Tissue Location | Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate as the fifth reaction of the cholesterol biosynthetic pathway.
References
Hogenboom, S., et al., J. Lipid Res. 45(4):697-705 (2004).Strausberg RL, et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Olivier, L.M., et al., J. Lipid Res. 40(4):672-679 (1999).Chambliss, K.L., et al., J. Biol. Chem. 271(29):17330-17334 (1996).Krisans, S.K., et al., J. Biol. Chem. 269(19):14165-14169 (1994).
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