|Other Names||NAD kinase, Poly(P)/ATP NAD kinase, NADK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7176a was selected from the N-term region of human PPNK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Widely expressed but not detected in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
NADP is essential for biosynthetic pathways, energy, and signal transduction. Its synthesis is catalyzed by NAD kinase, which phosphorylates NAD+ to form NADP+. The NAD kinase gene is expressed in most human tissues, but not in skeletal muscle. The catalytically active homotetramer is highly selective for its substrates, NAD and ATP.
Lerner, F., et al., Biochem. Biophys. Res. Commun. 288(1):69-74 (2001).
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