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PRPS1/PRPS2/PRPS3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P60891 |
|---|---|
| Other Accession | Q5JV75 |
| Clone Names | 4012121 |
| Gene ID | 5631 |
|---|---|
| Other Names | Ribose-phosphate pyrophosphokinase 1, PPRibP, Phosphoribosyl pyrophosphate synthase I, PRS-I, PRPS1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7178a was selected from the C-term region of human PRPS1/2/3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRPS1 (HGNC:9462) |
|---|---|
| Function | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphoribosylpyrophosphate synthetase (PRPS) catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for the de novo and salvage pathways of purine, pyrimidine, and pyridine biosynthesis. Defects in PRPS1 are the cause of PRPS-related gout, also known as gout due to PRPS1 superactivity. It is a familial disorder characterized by excessive purine production, gout and uric acid urolithiasis.
References
Ahmed, M., et al., J. Biol. Chem. 274(11):7482-7488 (1999).Ishijima, S., et al., Biochim. Biophys. Acta 1342(1):28-36 (1997).Becker, M.A., et al., J. Biol. Chem. 271(33):19894-19899 (1996).Roessler, B.J., et al., J. Biol. Chem. 268(35):26476-26481 (1993).Ishizuka, T., et al., Biochim. Biophys. Acta 1130(2):139-148 (1992).
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