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RFK Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q969G6
Clone Names 4022301
Additional Information
Gene ID 55312
Other Names Riboflavin kinase, ATP:riboflavin 5'-phosphotransferase, Flavokinase, RFK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7183a was selected from the N-term region of human RFK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RFK
Function Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF- activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Cellular Location Cytoplasm.
Tissue Location Detected in brain, placenta and urinary bladder.
Research Areas
Citations (0)
citation

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Background

RFK (riboflavin kinase) catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).

References

Karthikeyan, S., et al., Biochemistry 42(43):12532-12538 (2003).Karthikeyan, S., et al., Structure (Camb.) 11(3):265-273 (2003).

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$ 277.78
Cat# BP7183a
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