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AKR7A2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43488
Clone Names 80924048
Peptide ID 80924048
Additional Information
Gene ID 8574
Other Names Aflatoxin B1 aldehyde reductase member 2, 111n11, AFB1 aldehyde reductase 1, AFB1-AR 1, Aldoketoreductase 7, Succinic semialdehyde reductase, SSA reductase, AKR7A2, AFAR, AFAR1, AKR7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7186a was selected from the N-term region of human AKR7A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR7A2
Synonyms AFAR, AFAR1, AKR7
Function Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Cellular Location Golgi apparatus. Cytoplasm
Tissue Location Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts Detected at low levels in lung and pancreas (at protein level) Widely expressed.
Research Areas
Citations (0)

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AKR7A2 is aldo-keto reductases, which are involved in the detoxification of aldehydes and ketones.


Ireland L.S., Harrison D.J.Biochem. J. 332:21-34(1998)Kelly V.P., Sherratt P.J.Biochem. J. 366:847-861(2002)

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$ 80.00
Cat# BP7186a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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