|Other Names||Testis-specific serine/threonine-protein kinase 2, TSK-2, TSK2, TSSK-2, Testis-specific kinase 2, DiGeorge syndrome protein G, DGS-G, Serine/threonine-protein kinase 22B, TSSK2, DGSG, SPOGA2, STK22B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7190b was selected from the C-term region of human STK22B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DGSG, SPOGA2, STK22B|
|Function||Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis.|
|Tissue Location||Testis-specific. Present in mature spermatozoa (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
STK22B is involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. This protein may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies.
Hao, Z., et al., Mol. Hum. Reprod. 10(6):433-444 (2004).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Dunham, I., et al., Nature 402(6761):489-495 (1999).Gong, W., et al., Hum. Mol. Genet. 5(6):789-800 (1996).Collins, J.E., et al., Genome Biol. 5 (10), R84 (2004).
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