|Other Names||Uridine-cytidine kinase 2, UCK 2, Cytidine monophosphokinase 2, Testis-specific protein TSA903, Uridine monophosphokinase 2, UCK2, UMPK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7192b was selected from the C-term region of human UCK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.|
|Tissue Location||According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific|
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Provided below are standard protocols that you may find useful for product applications.
UCK2 catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.
Murata, D., et al., Drug Metab. Dispos. 32(10):1178-1182 (2004).Pasti, C., et al., Eur. J. Biochem. 270(8):1784-1790 (2003).Liou, J.Y., et al., Cancer Res. 62(6):1624-1631 (2002).Pearman, A.T., et al., Life Sci. 69(20):2361-2370 (2001).Van Rompay, A.R., et al., Mol. Pharmacol. 56(3):562-569 (1999).
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