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HMGB2 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P26583
Clone Names 81020152
Peptide ID 81020152
Additional Information
Gene ID 3148
Other Names High mobility group protein B2, High mobility group protein 2, HMG-2, HMGB2, HMG2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7195c was selected from the Center region of human HMGB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMGB2
Synonyms HMG2
Function DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity).
Cellular Location Nucleus. Chromosome.
Research Areas
Citations (0)

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HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.


Majumdar A., Brown D. 19:6643-6643(1991)Shirakawa H., Yoshida M.J.. 267:6641-6645(1992)Alexandre S., Li W.W.Nucleic Acids Res. 20:6413-6413(1992)Fan Z., Beresford P.J.Mol. Cell. Biol. 22:2810-2820(2002)

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$ 80.00
Cat# BP7195c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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