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PTK9 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q12792 |
|---|---|
| Other Accession | Q6NUK9 |
| Clone Names | 6031653 |
| Gene ID | 5756 |
|---|---|
| Other Names | Twinfilin-1, Protein A6, Protein tyrosine kinase 9, TWF1, PTK9 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7198a was selected from the N-terminal region of human PTK9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TWF1 |
|---|---|
| Synonyms | PTK9 |
| Function | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). |
| Tissue Location | Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.
References
Vartiainen, M.K., et al., J. Biol. Chem. 278(36):34347-34355 (2003).Ojala, P.J., et al., Mol. Biol. Cell 13(11):3811-3821 (2002).Beeler, J.F., et al., Mol. Cell. Biol. 14(2):982-988 (1994).Palmgren, S., et al., J. Cell. Sci. 115 (Pt 5), 881-886 (2002) (): ().
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