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ERK1 Antibody (D192) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP7251f | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ERK1 Antibody (D192) Blocking Peptide - Product info | |
| Primary Accession | P27361 |
| Clone Names | 80215112 |
| Calculated MW | 43136 Da |
ERK1 Antibody (D192) Blocking Peptide - Additional info | |
| Gene ID 5595 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7251f was selected from the D192 region of human ERK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
ERK1 Antibody (D192) Blocking Peptide - Protein Information | |
| Name MAPK3 | |
| Synonyms ERK1, PRKM3 | |
| Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10) Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade | |
| Cellular Location Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization | |
ERK1 Antibody (D192) Blocking Peptide - Related products
AP3605a: Phospho-MAPK3-pT202 Antibody
AP3606a: Phospho-MAPK3-pY204 Antibody
AP3607a: Bi-phospho-ERK1/2-T202/Y204 Antibody
AP7251a: MAPK3 Antibody (N-term)
AP7251b: MAPK3 Antibody (C-term)
AP7251d: MAPK3 Antibody (T202)
AP7251e: MAPK3 Antibody (Y204)
AP7251f: MAPK3 Antibody (D192)
AP7500a: MAPK3 Antibody (N-term)
RI13190: MAPK3 predesign siRNA
LY10587a: MAPK3 Over-expression Lysate
BP3605a: Phospho-ERK1-pT202 Antibody Blocking Peptide
BP3606a: Phospho-ERK1-pY204 Antibody Blocking Peptide
BP3607a: Phospho-ERK1-pT202/pY204 Antibody Blocking Peptide
BP7251a: MAPK3 Antibody (N-term) Blocking Peptide
BP7251b: MAPK3 Antibody (C-term) Blocking Peptide
BP7251d: MAPK3 Antibody (T202) Blocking Peptide
BP7251e: MAPK3 Antibody (Y204) Blocking Peptide
BP7251f: ERK1 Antibody (D192) Blocking Peptide
BP7500a: ERK1 Antibody (N-term) Blocking Peptide
AT2789a: MAPK3 Antibody (monoclonal) (M01)
AT2790a: MAPK3 Antibody (monoclonal) (M02)
AT2791a: MAPK3 Antibody (monoclonal) (M03)
AJ1271a: MAPK3 Antibody (C-term)
AJ1271b: Phospho-MAPK3-pT202/T204 Antibody
AJ1458a: MAPK3 Antibody (N-term)
AJ1602a: Phospho-Erk1 (pT202/pY204) / Erk2 (pT185/pY187) Antibody
ERK1 Antibody (D192) Blocking Peptide - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MAPK3 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets.
REFERENCES
Munshi, H.G., et al., J. Biol. Chem. 279(37):39042-39050 (2004).Mukherjee, S., et al., Infect. Immun. 72(9):5274-5282 (2004).Sebkova, L., et al., Infect. Immun. 72(9):5019-5026 (2004).Huang, H.M., et al., Biochem. Biophys. Res. Commun. 320(4):1247-1252 (2004).Mizuno, S., et al., Am. J. Respir. Cell Mol. Biol. 31(2):184-192 (2004).
