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EIF3S1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75822
Clone Names 71213101
Peptide ID 71213101
Additional Information
Gene ID 8669
Other Names Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009}, eIF3j {ECO:0000255|HAMAP-Rule:MF_03009}, Eukaryotic translation initiation factor 3 subunit 1 {ECO:0000255|HAMAP-Rule:MF_03009}, eIF-3-alpha {ECO:0000255|HAMAP-Rule:MF_03009}, eIF3 p35 {ECO:0000255|HAMAP-Rule:MF_03009}, EIF3J {ECO:0000255|HAMAP-Rule:MF_03009}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7261c was selected from the N-term region of human EIF3S1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF3J {ECO:0000255|HAMAP-Rule:MF_03009}
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
Research Areas
Citations (0)

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Eukaryotic initiation factor-3 (EIF3) has a molecular mass of about 600 kD and contains 13 nonidentical protein subunits, including EIF3J. EIF3 plays a central role in binding of initiator methionyl-tRNA and mRNA to the 40S ribosomal subunit to form the 40S initiation complex.


Fraser,C.S., Mol. Cell 26 (6), 811-819 (2007)ElAntak,L., J. Biol. Chem. 282 (11), 8165-8174 (2007)Fraser,C.S., J. Biol. Chem. 279 (10), 8946-8956 (2004)

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$ 80.00
Cat# BP7261c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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