|Other Names||DET1 homolog, De-etiolated-1 homolog, DET1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7271b was selected from the C-term region of human DET1 ANtibody (C-term). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.|
|Tissue Location||Highly expressed in the ovary, some lymphoid organs and resting leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
DET1 is a component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
Pick,E., Mol. Cell. Biol. 27 (13), 4708-4719 (2007)Wertz,I.E., Science 303 (5662), 1371-1374 (2004)
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