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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TGIF Antibody (Center L223) Blocking peptide   

TGIF Antibody (Center L223) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15583
Clone Names 71017128
Peptide ID 71017128
Additional Information
Gene ID 7050
Other Names Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7279c was selected from the Center region of human TGIF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGIF1
Synonyms TGIF
Function Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.

References

Pertile,K.K., Invest. Ophthalmol. Vis. Sci. 49 (1), 49-54 (2008)Chavarria-Siles,I., Mol. Psychiatry 12 (11), 1033-1041 (2007)Ferrand,N., FASEB J. 21 (2), 488-496 (2007)

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$ 80.00
Cat# BP7279c
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