|Other Names||NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7281a was selected from the N-term region of human NALP12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP12, PYPAF7, RNO|
|Function||May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.|
|Tissue Location||Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Ye,Z., Mol. Cell. Biol. 28 (5), 1841-1850 (2008)Jeru,I., Proc. Natl. Acad. Sci. U.S.A. 105 (5), 1614-1619 (2008)Arthur,J.C., J. Immunol. 179 (9), 6291-6296 (2007)
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