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MAPK8IP3 Antibody (S583) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UPT6
Clone Names 109139
Additional Information
Gene ID 23162
Other Names C-Jun-amino-terminal kinase-interacting protein 3, JIP-3, JNK-interacting protein 3, JNK MAP kinase scaffold protein 3, Mitogen-activated protein kinase 8-interacting protein 3, MAPK8IP3, JIP3, KIAA1066
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7282c was selected from the S583 region of human MAPK8IP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPK8IP3
Synonyms JIP3, KIAA1066
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport.

References

Choy,K.W., Physiol. Genomics 25 (1), 9-15 (2006)Oh,J.H., Mamm. Genome 16 (12), 942-954 (2005)Takino,T., J. Biol. Chem. 280 (45), 37772-37781 (2005)

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$ 80.00
Cat# BP7282c
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