|Other Names||C-Jun-amino-terminal kinase-interacting protein 3, JIP-3, JNK-interacting protein 3, JNK MAP kinase scaffold protein 3, Mitogen-activated protein kinase 8-interacting protein 3, MAPK8IP3, JIP3, KIAA1066|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7282c was selected from the S583 region of human MAPK8IP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).|
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MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport.
Choy,K.W., Physiol. Genomics 25 (1), 9-15 (2006)Oh,J.H., Mamm. Genome 16 (12), 942-954 (2005)Takino,T., J. Biol. Chem. 280 (45), 37772-37781 (2005)
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