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Parg Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86W56
Clone Names 71113057
Additional Information
Gene ID 670;8505
Other Names Poly(ADP-ribose) glycohydrolase, PARG
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7283a was selected from the N-term region of human Parg. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters.
Cellular Location Isoform 1: Nucleus Note=Colocalizes with PCNA at replication foci. Relocalizes to the cytoplasm in response to DNA damage Isoform 3: Cytoplasm. Isoform 5: Mitochondrion matrix.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.


Meyer,R.G., Exp. Cell Res. 313 (13), 2920-2936 (2007)Fisher,A.E., Mol. Cell. Biol. 27 (15), 5597-5605 (2007)Keil,C., J. Biol. Chem. 281 (45), 34394-34405 (2006)

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$ 80.00
Cat# BP7283a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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