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PBX1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P40424
Clone Names 6071562
Peptide ID 6071562
Additional Information
Gene ID 5087
Other Names Pre-B-cell leukemia transcription factor 1, Homeobox protein PBX1, Homeobox protein PRL, PBX1, PRL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7285b was selected from the C-term region of human PBX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PBX1
Synonyms PRL
Function Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Expressed in all tissues except in cells of the B and T lineage
Research Areas
Citations (0)

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PBX1 binds the sequence 5'-ATCAATCAA-3'. It acts as a transcriptional activator of PF4 in complex with MEIS1, and is converted into a potent transcriptional activator by the (1;19) translocation. It may have a role in steroidogenesis and, subsequently, sexual development and differentiation.


Duesing,K., BMC Med. Genet. 9, 14 (2008)Chung,E.Y., Immunity 27 (6), 952-964 (2007)Qiu,Y., Am. J. Pathol. 170 (1), 152-159 (2007)

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$ 80.00
Cat# BP7285b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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