|Other Names||Nucleoside diphosphate-linked moiety X motif 6, Nudix motif 6, 361-, Antisense basic fibroblast growth factor, Protein GFG, NUDT6, FGF2AS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7288b was selected from the C-term region of human NUDT6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to the regulation of cell proliferation.|
|Cellular Location||Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms|
|Tissue Location||Detected in liver, kidney and esophagus (at protein level). Ubiquitous.|
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Provided below are standard protocols that you may find useful for product applications.
FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing. Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.
Xiao,D.,Acta Biochim. Biophys. Sin. (Shanghai) 40 (4), 297-303 (2008)Zhang,S.C., J. Mol. Med. 85 (11), 1215-1228 (2007)Pezzatini,S., Bone 41 (4), 523-534 (2007)
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