|Other Names||Cyclin-A2, Cyclin-A, CCNA2, CCN1, CCNA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7292a was selected from the N-term region of human CCNA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.|
|Cellular Location||Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER|
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Provided below are standard protocols that you may find useful for product applications.
CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Henglein B.,Proc. Natl. Acad. Sci. U.S.A. 91:5490-5494(1994)Wang J.,Nature 343:555-557(1990)Tsang,W.Y.,J. Cell Biol. 178 (4), 621-633 (2007)
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