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LAP3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P28838
Clone Names 71213133
Additional Information
Gene ID 51056
Other Names Cytosol aminopeptidase, Leucine aminopeptidase 3, LAP-3, Leucyl aminopeptidase, Peptidase S, Proline aminopeptidase, Prolyl aminopeptidase, LAP3, LAPEP, PEPS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7296b was selected from the C-term region of human LAP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAP3 (HGNC:18449)
Function Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S- conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q68FS4}.
Research Areas
Citations (0)
citation

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Background

LAP3 is presumably involved in the processing and regular turnover of intracellular proteins. It catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro.

References

Goto,Y.,FEBS Lett. 580 (7), 1833-1838 (2006)Matsushima,M.,Biochem. Biophys. Res. Commun. 178 (3), 1459-1464 (1991)

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$ 277.78
Cat# BP7296b
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