LAP3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P28838 |
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Clone Names | 71213133 |
Gene ID | 51056 |
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Other Names | Cytosol aminopeptidase, Leucine aminopeptidase 3, LAP-3, Leucyl aminopeptidase, Peptidase S, Proline aminopeptidase, Prolyl aminopeptidase, LAP3, LAPEP, PEPS |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7296b was selected from the C-term region of human LAP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LAP3 (HGNC:18449) |
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Function | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S- conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q68FS4}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LAP3 is presumably involved in the processing and regular turnover of intracellular proteins. It catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro.
References
Goto,Y.,FEBS Lett. 580 (7), 1833-1838 (2006)Matsushima,M.,Biochem. Biophys. Res. Commun. 178 (3), 1459-1464 (1991)
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