|Other Names||Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B, LEFTY1, LEFTB, LEFTYB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7297b was selected from the C-term region of human LEFTB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for left-right axis determination as a regulator of LEFTY2 and NODAL.|
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Provided below are standard protocols that you may find useful for product applications.
LEFTB is a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products.
Kosaki K.,Am. J. Hum. Genet. 64:712-721(1999)Dvash,T.,Stem Cells 25 (2), 465-472 (2007)Besser,D.,J. Biol. Chem. 279 (43), 45076-45084 (2004)
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