|Other Names||Carbonic anhydrase 14, Carbonate dehydratase XIV, Carbonic anhydrase XIV, CA-XIV, CA14|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7306a was selected from the N-term region of human CA14. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
CA14 belongs a large family of zinc metalloenzymes that catalyze the versible hydration of carbon dioxide. The protein is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.
Parkkila,S. Natl. Acad. Sci. U.S.A. 98 (4), 1918-1923 (2001)Fujikawa-Adachi,K., Nishimori,I. Genomics 61 (1), 74-81 (1999)Tarun,A.S., Bryant,B. Chem. Senses 28 (7), 621-629 (2003)
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