|Other Names||Carbonic anhydrase 2, Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II, CA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7307b was selected from the C-term region of human CA2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells|
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Provided below are standard protocols that you may find useful for product applications.
CA2 is one of several (at least 7) isozymes of carbonic anhydrase. The protein catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis.
Fisher,S.Z. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 5), 495-498 (2009)Adamus,G. and Karren,L. J. Autoimmun. 32 (2), 133-139 (2009)Hu,P.Y., Roth,D.E. Hum. Mutat. 1 (4), 288-292 (1992)
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