|Other Names||Carbonic anhydrase 5B, mitochondrial, Carbonate dehydratase VB, Carbonic anhydrase VB, CA-VB, CA5B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7308a was selected from the N-term region of human CA5B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide.|
|Tissue Location||Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver|
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Provided below are standard protocols that you may find useful for product applications.
CA5B belongs a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. This protein is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. The protein has a wider tissue distribution than CA VA, which is restricted to the liver.
Vullo,D., Nishimori,I. Bioorg. Med. Chem. Lett. 17 (5), 1336-1340 (2007)Shah,G.N. Proc. Natl. Acad. Sci. U.S.A. 97 (4), 1677-1682 (2000)Fujikawa-Adachi,K. J. Biol. Chem. 274 (30), 21228-21233 (1999)
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