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CAPN3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P20807 |
|---|---|
| Clone Names | 80411166 |
| Gene ID | 825 |
|---|---|
| Other Names | Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7309c was selected from the Center region of human CAPN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CAPN3 (HGNC:1480) |
|---|---|
| Synonyms | CANP3, CANPL3, NCL1 |
| Function | Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). |
| Cellular Location | Cytoplasm. Nucleus, nucleolus |
| Tissue Location | Isoform I is skeletal muscle specific. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CAPN3, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. The protein is a muscle-specific member of the calpain large subunit family that specifically binds to titin.
References
Moretti,D., Del Bello,B. Carcinogenesis 30 (6), 960-967 (2009)Beckmann,J.S. and Spencer,M. Neuromuscul. Disord. 18 (12), 913-921 (2008)Kramerova,I., Kudryashova,E. Hum. Mol. Genet. 17 (21), 3271-3280 (2008)Sorimachi,H., Kinbara,K. J. Biol. Chem. 270 (52), 31158-31162 (1995)
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