|Other Names||Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7309c was selected from the Center region of human CAPN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CANP3, CANPL3, NCL1|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
|Tissue Location||Isoform I is skeletal muscle specific.|
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Provided below are standard protocols that you may find useful for product applications.
CAPN3, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. The protein is a muscle-specific member of the calpain large subunit family that specifically binds to titin.
Moretti,D., Del Bello,B. Carcinogenesis 30 (6), 960-967 (2009)Beckmann,J.S. and Spencer,M. Neuromuscul. Disord. 18 (12), 913-921 (2008)Kramerova,I., Kudryashova,E. Hum. Mol. Genet. 17 (21), 3271-3280 (2008)Sorimachi,H., Kinbara,K. J. Biol. Chem. 270 (52), 31158-31162 (1995)
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