|Other Names||Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7309c was selected from the Center region of human CAPN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CANP3, CANPL3, NCL1|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
|Tissue Location||Isoform I is skeletal muscle specific.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CAPN3, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. The protein is a muscle-specific member of the calpain large subunit family that specifically binds to titin.
Moretti,D., Del Bello,B. Carcinogenesis 30 (6), 960-967 (2009)Beckmann,J.S. and Spencer,M. Neuromuscul. Disord. 18 (12), 913-921 (2008)Kramerova,I., Kudryashova,E. Hum. Mol. Genet. 17 (21), 3271-3280 (2008)Sorimachi,H., Kinbara,K. J. Biol. Chem. 270 (52), 31158-31162 (1995)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.