|Other Names||Calpain-9, 3422-, Digestive tract-specific calpain, New calpain 4, nCL-4, Protein CG36, CAPN9, NCL4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7310a was selected from the N-term region of human CAPN9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
|Tissue Location||Expressed predominantly in stomach.|
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Provided below are standard protocols that you may find useful for product applications.
CAPN9 has been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This protein is thought to be associated with gastric cancer.
Huang,Y. and Wang,K.K. Trends Mol Med 7 (8), 355-362 (2001)Lee,H.J., Tomioka,S. Arch. Biochem. Biophys. 362 (1), 22-31 (1999)Lee,H.J., Sorimachi,H. Biol. Chem. 379 (2), 175-183 (1998)Suzuki,K., Sorimachi,H. Biol. Chem. Hoppe-Seyler 376 (9), 523-529 (1995)
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