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PLG Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P00747
Clone Names 80917060
Additional Information
Gene ID 5340
Other Names Plasminogen, Plasmin heavy chain A, Activation peptide, Angiostatin, Plasmin heavy chain A, short form, Plasmin light chain B, PLG
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7313b was selected from the C-term region of human PLG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLG
Function Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Cellular Location Secreted. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface
Tissue Location Present in plasma and many other extracellular fluids. It is synthesized in the liver
Research Areas
Citations (0)
citation

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Background

PLG is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg560 and val561, which is mediated by urokinase and tissue plasminogen activator. The main function of this protein is to dissolve fibrin clots. The protein, like trypsin, belongs to the family of serine proteinases.

References

Hofmann,S.C., Voith,U. J. Invest. Dermatol. 129 (7), 1730-1739 (2009)Passero,C.J., Mueller,G.M. J. Biol. Chem. 283 (52), 36586-36591 (2008)Ohyama,S., Harada,T. Eur. J. Biochem. 271 (4), 809-820 (2004)Lee,H., Kim,H.K. Arch. Biochem. Biophys. 375 (2), 359-363 (2000)

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$ 277.78
Cat# BP7313b
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