|Other Names||Pigment epithelium-derived factor, PEDF, Cell proliferation-inducing gene 35 protein, EPC-1, Serpin F1, SERPINF1, PEDF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7315a was selected from the N-term region of human SERPINF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.|
|Cellular Location||Secreted. Melanosome. Note=Enriched in stage I melanosomes|
|Tissue Location||Retinal pigment epithelial cells and blood plasma.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINF1 is a member of the serpin family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.
Bessho,H., Kondo,N. Mol. Vis. 15, 1107-1114 (2009)Petersen,S.V., Valnickova,Z. Biochem. J. 374 (PT 1), 199-206 (2003)Tombran-Tink,J., Pawar,H. Genomics 19 (2), 266-272 (1994)
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