|Other Names||DNA polymerase epsilon subunit 3, Arsenic-transactivated protein, AsTP, Chromatin accessibility complex 17 kDa protein, CHRAC-17, HuCHRAC17, DNA polymerase II subunit 3, DNA polymerase epsilon subunit p17, POLE3, CHRAC17|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7316a was selected from the N-term region of human POLE3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.|
|Tissue Location||Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.
Bolognese,F., Imbriano,C. Nucleic Acids Res. 28 (19), 3830-3838 (2000)Li,Y., Pursell,Z.F. J. Biol. Chem. 275 (30), 23247-23252 (2000)
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